I am currently in the same room with a scanning-tunnelling electron microscope. Its carrying case is the size of a large briefcase. So far, we're not being allowed to play with it.
The ones used for cutting-edge research still fill a room. It's hard to make an elaborate vacuum chamber and set of vibration dampeners small. The little ones don't require a vacuum and have a certain amount of fault-tolerance, but have corresponding limits on the resolution you can expect from them.
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